CardiologyCardiology

Modified Duke Criteria for Infective Endocarditis

Classifies IE likelihood using major and minor clinical, microbiological, and echocardiographic criteria. Guides diagnostic workup and treatment decisions.

MAJOR: Positive blood cultures — typical organism (viridans streptococci, S. bovis, HACEK, S. aureus, enterococci) in ≥2 separate cultures OR persistently positive?

MAJOR: Evidence of endocardial involvement on echocardiogram (oscillating intracardiac mass, abscess, new prosthetic valve dehiscence, or new valvular regurgitation)?

MINOR: Predisposing heart condition or IV drug use?

MINOR: Fever ≥ 38°C?

MINOR: Vascular phenomena (arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial haemorrhage, conjunctival haemorrhage, Janeway lesions)?

MINOR: Immunological phenomena (glomerulonephritis, Osler nodes, Roth spots, positive rheumatoid factor)?

MINOR: Microbiological evidence — positive blood cultures not meeting major criteria?

Reference: Li JS et al. Clin Infect Dis 2000 (Modified Duke Criteria)

Medical Disclaimer: This calculator is a clinical decision support tool for qualified healthcare professionals. It does not replace clinical judgement. Always interpret results in the full clinical context. Reference: Li JS et al. Clin Infect Dis 2000 (Modified Duke Criteria).

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