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👤 Adult

Tolvaptan

Clinically reviewed by MedNext Clinical Team. Last reviewed 1 January 2026. See our editorial policy and correction policy.

31 known interactions (1 severe)
2 brand names

Indications

  • Autosomal dominant polycystic kidney disease in adults with CKD stage 1 to 4 at initiation of treatment with evidence of rapidly progressing disease (initiated by a specialist)
  • Hyponatraemia secondary to syndrome of inappropriate antidiuretic hormone secretion (initiated in hospital or under specialist supervision)

Drug Interactions

1 SevereModerate interactions

31 drug interactions identified for Tolvaptan. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

General cautions: Abnormal liver function tests and/or signs or symptoms of liver injury (do not initiate if the criteria for permanent discontinuation are met—consult product literature); diabetes me

Side Effects

Common or very common Appetite decreased; asthenia; constipation; dehydration; diarrhoea; dizziness; dry mouth; dyspnoea; gastrointestinal discomfort;...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Jinarc(IN, SA, AE, EG, ZA, NG)Samsca(IN, PK)
Mn

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In the MedNext App

  • Complete dosing regimens
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  • All 2 brand names
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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Reviewer: MedNext Clinical Team

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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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