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👤 Adult

Tolcapone

Clinically reviewed by MedNext Clinical Team. Last reviewed 1 January 2026. See our editorial policy and correction policy.

13 known interactions
1 brand name

Indications

  • Adjunct to co-beneldopa or co-careldopa in Parkinson's disease with ‘end-of-dose’ motor fluctuations if another inhibitor of peripheral catechol-O-methyltransferase inappropriate (under expert supervision)

Drug Interactions

Moderate interactionsMinor interactions

13 drug interactions identified for Tolcapone. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

Most patients receiving more than 600 mg levodopa daily require reduction of levodopa dose by about 30% Cautions, further information Hepatotoxicity Potentially life-threatening hepatotoxicity includi

Side Effects

Commoninfluen

Full side effect profile available in the MedNext app.

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Tasmar(IN, PK, SA, AE, EG, ZA, NG)
Mn

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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Reviewer: MedNext Clinical Team

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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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