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👤 Adult👶 Paediatric

Simvastatin

Clinically reviewed by MedNext Clinical Team. Last reviewed 1 January 2026. See our editorial policy and correction policy.

73 known interactions (4 severe)
3 brand names

Indications

  • Primary hypercholesterolaemia, or combined (mixed) hyperlipidaemia in patients who have not responded adequately to diet and other appropriate measures
  • Homozygous familial hypercholesterolaemia in patients who have not responded adequately to diet and other appropriate measures
  • Prevention of cardiovascular events in patients with atherosclerotic cardiovascular disease or diabetes mellitus

Drug Interactions

4 SevereModerate interactionsMinor interactions

73 drug interactions identified for Simvastatin. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

statins Risk factors for muscle toxicity, including myopathy or rhabdomyolysis Cautions, further information Muscle effects Muscle toxicity can occur with all statins, however the likelihood increases

Side Effects

statins Common or very common Arthralgia; asthenia; constipation; diarrhoea; dizziness; flatulence; gastrointestinal discomfort; headache; muscle comp...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Zocor(IN, PK, SA, AE, EG, ZA, NG)Simvas(IN)+ 1 more in app
Mn

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  • Complete dosing regimens
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  • All 3 brand names
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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Reviewer: MedNext Clinical Team

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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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