Naloxone Hydrochloride
Clinically reviewed by MedNext Clinical Team. Last reviewed 1 January 2026. See our editorial policy and correction policy.
Indications
- Acute opioid overdose–high-dose regimen [when rapid titration with naloxone is necessary to reverse potentially life-threatening effects]
- Opioid overdose–low-dose regimen [when there is risk of acute withdrawal, or when a continued therapeutic effect is required (e.g. postoperative use, palliative care)]
- Opioid overdose in non-medical and medical settings
+ 2 more indications in the full monograph
Drug Interactions
7 drug interactions identified for Naloxone Hydrochloride. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.
Check Interactions in AppSafety Information
Cautions
hydrochloride Cardiovascular disease or those receiving cardiotoxic drugs (serious adverse cardiovascular effects reported); chronic opioid use (risk of acute withdrawal); maternal chronic opioid use
Side Effects
hydrochloride General side-effects: Common or very common Arrhythmias; dizziness; headache; hypertension; hypotension; nausea; vomiting Uncommon Diarr...
Full safety information, contraindications, and dosing available in the MedNext app.
Brand Names
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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.
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