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👤 Adult

Mexiletine

Clinically reviewed by MedNext Clinical Team. Last reviewed 1 January 2026. See our editorial policy and correction policy.

27 known interactions
1 brand name

Indications

  • Life-threatening ventricular arrhythmias (specialist use only)
  • Myotonia in non-dystrophic myotonic disorders

Drug Interactions

Moderate interactions

27 drug interactions identified for Mexiletine. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

General cautions: Epilepsy or history of seizures (increased risk of seizures); poor CYP2D6 metabolisers (increased plasma levels) Specific cautions: When used for myotonia Cardiac disorders other tha

Side Effects

Common or very common Angina pectoris; arrhythmias; asthenia; ataxia; chest discomfort; constipation; dizziness; drowsiness; dry mouth; gastrointestin...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Mexitil(IN, PK, SA, AE, EG, ZA, NG)
Mn

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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Reviewer: MedNext Clinical Team

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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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