Skip to main content
MedNextMedNext
👤 Adult👶 Paediatric

Methotrexate

Clinically reviewed by MedNext Clinical Team. Last reviewed 1 January 2026. See our editorial policy and correction policy.

36 known interactions (3 severe)
3 brand names

Indications

  • Mild to moderate Crohn's disease refractory or intolerant to thiopurines (under expert supervision)
  • Severe Crohn's disease (under expert supervision)
  • Maintenance of remission of severe Crohn's disease (under expert supervision)

+ 2 more indications in the full monograph

Drug Interactions

3 SevereModerate interactions

36 drug interactions identified for Methotrexate. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

Check Interactions in App

Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

Important safety information For methotrexate NHS Never Event: Overdose of methotrexate for non-cancer treatment (January 2018) Patients given methotrexate, by any route, for non-cancer treatment shou

Side Effects

UncommonCommon or very common With oral use Anaemia, appetite decreased

Full side effect profile available in the MedNext app.

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Folitrax(IN)Imutrex(IN)+ 1 more in app
Mn

Get the Full Monograph

Complete dosing, interactions, contraindications, side effects, and more for Methotrexate.

Download Free — 7-Day Trial

No credit card required

AES-256 EncryptedNo Patient Data

In the MedNext App

  • Complete dosing regimens
  • Full interaction details & severity
  • AI-powered drug search
  • All 3 brand names
  • Dosing calculators
  • CME/CPD tracking
  • 40 language support
  • Offline access

Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Reviewer: MedNext Clinical Team

Related drugs

Explore other drugs in the same clinical area or patient population.

Abacavir

Not classified · 18 interactions

Abacavir With Dolutegravir And Lamivudine

Not classified · 0 interactions

Abacavir With Lamivudine

Not classified · 49 interactions

Abacavir With Lamivudine And Zidovudine

Not classified · 0 interactions

Abaloparatide

Not classified · 5 interactions

Abatacept

Not classified · 13 interactions

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

Access all 2866 drugs in the MedNext app

Complete monographs, AI-powered search, interaction checker, dosing calculators, and CME tracking — in 40 languages.

Download MedNext — Free 7-Day Trial