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👤 Adult

Colesevelam Hydrochloride

Clinically reviewed by MedNext Clinical Team. Last reviewed 1 January 2026. See our editorial policy and correction policy.

33 known interactions (2 severe)
2 brand names

Indications

  • Primary hypercholesterolaemia as an adjunct to dietary measures [monotherapy]
  • Primary hypercholesterolaemia as an adjunct to dietary measures [in combination with a statin], Primary and familial hypercholesterolaemia [in combination with ezetimibe, either with or without a statin]
  • Bile acid malabsorption

Drug Interactions

2 SevereModerate interactionsMinor interactions

33 drug interactions identified for Colesevelam Hydrochloride. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫁Hepatic impairment guidance

Cautions

bile acid sequestrants Interference with the absorption of fat-soluble vitamins (supplements of vitamins A, D, K, and folic acid may be required when treatment is prolonged). Cautions For colesevelam

Side Effects

bile acid sequestrants Common or very common Constipation; dyspepsia; nausea; vomiting Rare or very rare Intestinal obstruction Side-effects For coles...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Welchol(IN)Cholestagel(IN, PK, SA, AE, EG, ZA, NG)
Mn

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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Reviewer: MedNext Clinical Team

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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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