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👤 Adult👶 Paediatric

Amitriptyline Hydrochloride

Clinically reviewed by MedNext Clinical Team. Last reviewed 1 January 2026. See our editorial policy and correction policy.

20 known interactions
5 brand names

Indications

  • Abdominal pain or discomfort (in patients who have not responded to laxatives, loperamide, or antispasmodics)
  • Major depressive disorder [not recommended—increased risk of fatality in overdose]
  • Major depressive disorder in patients with cardiovascular disease [not recommended—increased risk of fatality in overdose]

+ 2 more indications in the full monograph

Drug Interactions

Moderate interactions

20 drug interactions identified for Amitriptyline Hydrochloride. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫁Hepatic impairment guidance

Cautions

hydrochloride Cardiovascular disease; chronic constipation; diabetes; epilepsy; history of bipolar disorder; history of psychosis; hyperthyroidism (risk of arrhythmias); increased intra-ocular pressur

Side Effects

Commondrowsine

Full side effect profile available in the MedNext app.

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Tryptomer(IN)Elavil(IN)+ 3 more in app
Mn

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In the MedNext App

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  • All 5 brand names
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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Reviewer: MedNext Clinical Team

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Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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