Clinical Guides Articles
23 articles in this category
The Complete Guide to Warfarin Drug Interactions: What Every Prescriber Must Know
A comprehensive prescriber-focused guide to warfarin drug interactions: CYP2C9 inhibitors and inducers, pharmacodynamic interactions, dietary vitamin K, INR monitoring strategy, and a practical management framework for safe co-prescribing.
Understanding Drug Interactions: A Clinical Guide
Drug interactions remain one of the leading causes of adverse drug events. Learn about the main types of interactions and how to identify them at the point of care.
Antibiotic Stewardship: What Every Prescriber Needs to Know
Antimicrobial resistance is one of the greatest threats to global health. Learn the core principles of antibiotic stewardship, how to choose narrow-spectrum agents, and when to de-escalate therapy.
Renal Dose Adjustment: A Practical Guide for Clinicians
Prescribing in patients with kidney disease requires careful dose adjustment to avoid toxicity and treatment failure. Learn how to estimate GFR, identify at-risk drugs, and use MedNext's renal dosing tools.
Drug Allergy and Cross-Reactivity: Clinical Decision Making
Penicillin allergy is the most commonly reported drug allergy, yet the vast majority of labelled patients are not truly allergic. Learn how cross-reactivity myths affect prescribing and what the evidence shows.
Warfarin Drug Interactions: The Complete Clinical Guide
Warfarin has one of the longest lists of drug interactions of any medicine in common use. Understanding CYP2C9 metabolism, common interacting drugs, and when to monitor INR more frequently is essential for safe prescribing.
Evidence-Based Prescribing: From Guidelines to Clinical Practice
Evidence-based medicine underpins modern prescribing, but applying population-level trial data to individual patients requires nuanced clinical judgement. Here is how to bridge the gap.
Amoxicillin: Indications, Dosing, and Resistance Patterns
Amoxicillin remains one of the most prescribed antibiotics worldwide. Understanding its spectrum, appropriate indications, and the growing challenge of resistance is essential for rational prescribing.
Metformin: First-Line Therapy for Type 2 Diabetes
Metformin has been the cornerstone of type 2 diabetes management for decades. Its cardiovascular benefits, safety record, and low cost make it uniquely valuable — but several misconceptions persist.
Atorvastatin: Cardiovascular Prevention and Statin Safety
Atorvastatin is the most prescribed statin worldwide. Understanding its evidence base for primary and secondary cardiovascular prevention, and its safety profile, is essential for every prescriber.
Amlodipine: A First-Line Choice for Hypertension
Amlodipine is widely used as first-line antihypertensive therapy. Its long half-life, established cardiovascular outcome data, and tolerability profile make it a cornerstone of modern hypertension management.
Levothyroxine: Optimising Thyroid Hormone Replacement
Levothyroxine is one of the most prescribed drugs in the world, yet suboptimal dosing, food interactions, and monitoring gaps remain common. Here is how to get thyroid replacement right.
Ramipril and ACE Inhibitors: Heart Failure and Beyond
ACE inhibitors remain a cornerstone of cardiovascular medicine. Understand ramipril dosing, monitoring, and when to switch to an ARB.
Sertraline: First-Line SSRI for Depression and Anxiety
Sertraline is one of the most widely prescribed SSRIs. A practical guide to initiation, titration, and managing discontinuation.
Doxycycline: Practical Prescribing Tips
From acne to Lyme disease, doxycycline is versatile. Learn about photosensitivity, oesophageal ulceration prevention, and key interactions.
Clopidogrel: Antiplatelet Therapy After Stents and Stroke
Dual antiplatelet therapy duration, PPI interactions, and genetic variation in clopidogrel metabolism.
Apixaban: Practical DOAC Prescribing Guide
Apixaban has become the most prescribed DOAC. A guide to AF stroke prevention, VTE treatment, renal dosing, and perioperative management.
Co-amoxiclav: When Amoxicillin Alone Isn’t Enough
Co-amoxiclav adds beta-lactamase coverage. Understand when to step up from amoxicillin and the hepatotoxicity risk.
Bisoprolol: Beta-Blocker Therapy for Heart Failure and AF
Bisoprolol is a first-line beta-blocker for heart failure and rate control in AF. Learn about titration, bradycardia, and contraindications.
Insulin Types: A Practical Guide to Initiation
Understanding basal, bolus, and mixed insulin regimens is essential for safe diabetes management.
Warfarin: INR Management and Common Interactions
Warfarin remains widely used despite DOACs. Master INR targets, food interactions, and over-anticoagulation management.
Losartan and ARBs: The ACE Inhibitor Alternative
When ACE inhibitor cough is intolerable, ARBs like losartan offer an effective alternative with renal protective benefits.
Rivaroxaban: Once-Daily DOAC Prescribing
Rivaroxaban offers once-daily dosing for AF and VTE. Understand the food requirement, renal thresholds, and bleeding management.