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👤 Adult👶 Paediatric

Urokinase

5 known interactions
2 brand names

Indications

  • Deep-vein thrombosis (thromboembolic occlusive vascular disease)
  • Pulmonary embolism (thromboembolic occlusive vascular disease)
  • Occlusive peripheral arterial disease (thromboembolic occlusive vascular disease)
  • Occluded central venous catheters (blocked by fibrin clots)
  • Occluded arteriovenous haemodialysis shunts (blocked by fibrin clots)

+ 2 more indications in the full monograph

Drug Interactions

Moderate interactions

5 drug interactions identified for Urokinase. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

fibrinolytics Conditions in which thrombolysis might give rise to embolic complications such as enlarged left atrium with atrial fibrillation (risk of dissolution of clot and subsequent embolisation);...

Side Effects

fibrinolytics Common or very common Anaphylactic reaction; angina pectoris; cardiac arrest; cardiogenic shock; chills; CNS haemorrhage; ecchymosis; fever; haemorrhage; heart failure; ischaemia recurre...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Urokinase(IN, PK, SA, AE, EG, ZA, NG)Medokinase(IN)
Mn

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In the MedNext App

  • Complete dosing regimens
  • Full interaction details & severity
  • AI-powered drug search
  • All 2 brand names
  • Dosing calculators
  • CME/CPD tracking
  • 40 language support
  • Offline access

Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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