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👤 Adult👶 Paediatric

Topiramate

51 known interactions (4 severe)
3 brand names

Indications

  • Monotherapy of generalised tonic-clonic seizures or focal seizures with or without secondary generalisation
  • Adjunctive treatment of generalised tonic-clonic seizures or focal seizures with or without secondary generalisation, Adjunctive treatment
  • Migraine prophylaxis

Drug Interactions

4 SevereModerate interactionsMinor interactions

51 drug interactions identified for Topiramate. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

Avoid in Acute porphyrias ; risk of metabolic acidosis; risk of nephrolithiasis—ensure adequate hydration (especially in strenuous activity or warm environment)...

Side Effects

Common or very common Alopecia; anaemia; anxiety; appetite abnormal; asthenia; behaviour abnormal; cognitive impairment; concentration impaired; confusion; constipation; cough; depression; diarrhoea; ...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Topamac(IN)Topaz(IN)+ 1 more in app
Mn

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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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