Tolcapone
Indications
- Adjunct to co-beneldopa or co-careldopa in Parkinson's disease with ‘end-of-dose’ motor fluctuations if another inhibitor of peripheral catechol-O-methyltransferase inappropriate (under expert supervision)
Drug Interactions
13 drug interactions identified for Tolcapone. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.
Check Interactions in AppSafety Information
Cautions
Most patients receiving more than 600 mg levodopa daily require reduction of levodopa dose by about 30% Cautions, further information Hepatotoxicity Potentially life-threatening hepatotoxicity includi...
Side Effects
Common or very common Appetite decreased; chest pain; confusion; constipation; diarrhoea; dizziness; drowsiness; dry mouth; gastrointestinal discomfort; hallucination; headache; hyperhidrosis; influen...
Full safety information, contraindications, and dosing available in the MedNext app.
Brand Names
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Source: MedNext Audited Proprietary Dataset
Last reviewed: 2026
Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.
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