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👤 Adult👶 Paediatric

Tacrolimus

72 known interactions (5 severe)
3 brand names

Indications

  • Short-term treatment of moderate to severe atopic eczema (including flares) in patients unresponsive to, or intolerant of conventional therapy (initiated by a specialist)
  • Prevention of flares in patients with moderate to severe atopic eczema and 4 or more flares a year who have responded to initial treatment with topical tacrolimus (initiated by a specialist)
  • Short-term treatment of facial, flexural, or genital psoriasis in patients unresponsive to, or intolerant of other topical therapy (initiated under specialist supervision)
  • Prophylaxis of graft rejection following liver transplantation, starting 12 hours after transplantation
  • Prophylaxis of graft rejection following kidney transplantation, starting within 24 hours of transplantation

+ 8 more indications in the full monograph

Drug Interactions

5 SevereModerate interactions

72 drug interactions identified for Tacrolimus. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫁Hepatic impairment guidance

Cautions

General cautions: UV light (avoid excessive exposure to sunlight and sunlamps) Specific cautions: With systemic use Increased risk of infections; increased susceptibility to lymphoproliferative disord...

Side Effects

General side-effects: Common or very common Increased risk of infection; sensation abnormal; skin reactions Frequency not known Neoplasms Specific side-effects: Common or very common With intravenous ...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Prograf(IN, PK, SA, AE, EG, ZA, NG)Pangraf(IN)+ 1 more in app
Mn

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In the MedNext App

  • Complete dosing regimens
  • Full interaction details & severity
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  • All 3 brand names
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  • CME/CPD tracking
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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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