👤 Adult👶 Paediatric

Pyrimethamine

8 known interactions (1 severe)

1 brand name

Indications

Toxoplasmosis in pregnancy (in combination with sulfadiazine and folinic acid)

Drug Interactions

1 SevereModerate interactions

8 drug interactions identified for Pyrimethamine. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available

🤱Breastfeeding guidance available

🫘Renal impairment guidance

🫁Hepatic impairment guidance

⚠️Requires renal dose adjustment

Cautions

History of seizures—avoid large loading doses; predisposition to folate deficiency...

Side Effects

Common or very common Anaemia; diarrhoea; dizziness; headache; leucopenia; nausea; skin reactions; thrombocytopenia; vomiting Uncommon Fever Rare or very rare Abdominal pain; oral ulceration; pancytop...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Daraprim(IN, PK, SA, AE, EG, ZA, NG)

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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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