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👤 Adult👶 Paediatric

Methotrexate

36 known interactions (3 severe)
3 brand names

Indications

  • Mild to moderate Crohn's disease refractory or intolerant to thiopurines (under expert supervision)
  • Severe Crohn's disease (under expert supervision)
  • Maintenance of remission of severe Crohn's disease (under expert supervision)
  • Moderate to severe active rheumatoid arthritis (under expert supervision)
  • Severe active rheumatoid arthritis (under expert supervision)

+ 2 more indications in the full monograph

Drug Interactions

3 SevereModerate interactions

36 drug interactions identified for Methotrexate. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

Important safety information For methotrexate NHS Never Event: Overdose of methotrexate for non-cancer treatment (January 2018) Patients given methotrexate, by any route, for non-cancer treatment shou...

Side Effects

General side-effects: Uncommon Seizure Specific side-effects: Common or very common With oral use Anaemia; appetite decreased; diarrhoea; drowsiness; fatigue; gastrointestinal discomfort; headache; in...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Folitrax(IN)Imutrex(IN)+ 1 more in app
Mn

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In the MedNext App

  • Complete dosing regimens
  • Full interaction details & severity
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  • All 3 brand names
  • Dosing calculators
  • CME/CPD tracking
  • 40 language support
  • Offline access

Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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