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👤 Adult

Leflunomide

30 known interactions (3 severe)
2 brand names

Indications

  • Moderate to severe active rheumatoid arthritis (specialist use only)
  • Active psoriatic arthritis (specialist use only)

Drug Interactions

3 SevereModerate interactions

30 drug interactions identified for Leflunomide. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

Anaemia (avoid if significant and due to causes other than rheumatoid or psoriatic arthritis); history of tuberculosis; impaired bone-marrow function (avoid if significant and due to causes other than...

Side Effects

Common or very common Abdominal pain; accelerated hair loss; appetite decreased; asthenia; diarrhoea; dizziness; gastrointestinal disorders; headache; hypersensitivity; hypertension; leucopenia; nause...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Arava(IN, PK, SA, AE, EG, ZA, NG)Lefno(IN)
Mn

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In the MedNext App

  • Complete dosing regimens
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  • All 2 brand names
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  • CME/CPD tracking
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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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