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👤 Adult👶 Paediatric

Lamotrigine

57 known interactions (5 severe)
2 brand names

Indications

  • Monotherapy of focal seizures, Monotherapy of primary and secondary generalised tonic-clonic seizures, Monotherapy of seizures associated with Lennox-Gastaut syndrome
  • Adjunctive therapy of focal seizures with valproate, Adjunctive therapy of primary and secondary generalised tonic-clonic seizures with valproate, Adjunctive therapy of seizures associated with Lennox-Gastaut syndrome with valproate
  • Adjunctive therapy of focal seizures (with enzyme inducing drugs) without valproate, Adjunctive therapy of primary and secondary generalised tonic-clonic seizures (with enzyme inducing drugs) without valproate, Adjunctive therapy of seizures associated with Lennox-Gastaut syndromes (with enzyme inducing drugs) without valproate
  • Adjunctive therapy of focal seizures (without enzyme inducing drugs) without valproate, Adjunctive therapy of primary and secondary generalised tonic-clonic seizures (without enzyme inducing drugs) without valproate, Adjunctive therapy of seizures associated with Lennox-Gastaut syndromes (without enzyme inducing drugs) without valproate
  • Monotherapy or adjunctive therapy of bipolar disorder (without enzyme inducing drugs) without valproate

+ 2 more indications in the full monograph

Drug Interactions

5 SevereModerate interactionsMinor interactions

57 drug interactions identified for Lamotrigine. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

Brugada syndrome; Parkinson’s disease (may be exacerbated) (in adults); seizures (may be exacerbated) Cautions, further information Seizure exacerbation Lamotrigine may exacerbate seizures in patients...

Side Effects

Common or very common Aggression; agitation; arthralgia; diarrhoea; dizziness; drowsiness; dry mouth; fatigue; headache; irritability; nausea; pain; rash; sleep disorders; tremor; vomiting Uncommon Al...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Lamictal(IN, PK, SA, AE, EG, ZA, NG)Lamitor(IN)
Mn

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In the MedNext App

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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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