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👤 Adult👶 Paediatric

Isoniazid

21 known interactions (2 severe)
3 brand names

Indications

  • Tuberculosis, in combination with other drugs (standard unsupervised 6-month treatment)
  • Tuberculosis, in combination with other drugs (intermittent supervised 6-month treatment) (under expert supervision)
  • Prevention of tuberculosis in susceptible close contacts or those who have become tuberculin positive

Drug Interactions

2 SevereModerate interactions

21 drug interactions identified for Isoniazid. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
🫁Hepatic impairment guidance
⚠️Requires renal dose adjustment

Cautions

Acute porphyrias ; alcohol dependence; diabetes mellitus; epilepsy; history of psychosis; HIV infection; malnutrition; slow acetylator status (increased risk of side-effects) Cautions, further informa...

Side Effects

General side-effects: Uncommon Hepatic disorders Rare or very rare Severe cutaneous adverse reactions (SCARs) Frequency not known Agranulocytosis; aplastic anaemia; fever; gynaecomastia; haemolytic an...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

INH(IN)Isokin(IN)+ 1 more in app
Mn

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In the MedNext App

  • Complete dosing regimens
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  • All 3 brand names
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Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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