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👤 Adult👶 Paediatric

Denosumab

4 known interactions
2 brand names

Indications

  • Osteoporosis in postmenopausal women and in men at increased risk of fractures, Bone loss associated with hormone ablation in men with prostate cancer at increased risk of fractures, Bone loss associated with long-term systemic glucocorticoid therapy in patients at increased risk of fracture
  • Prevention of skeletal related events in patients with bone metastases
  • Giant cell tumour of bone that is unresectable or where surgical resection is likely to result in severe morbidity

Drug Interactions

Moderate interactions

4 drug interactions identified for Denosumab. Check the full interaction details, severity ratings, and clinical recommendations in the MedNext app.

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Safety Information

🤰Pregnancy guidance available
🤱Breastfeeding guidance available
🫘Renal impairment guidance
⚠️Requires renal dose adjustment

Cautions

Risk factors for osteonecrosis of the external auditory canal; risk factors for osteonecrosis of the jaw—consider temporary interruption of denosumab if occurs during treatment Cautions For Prolia® Wh...

Side Effects

Common or very common Abdominal discomfort; alopecia; constipation; diarrhoea; dyspnoea; hyperhidrosis; hypocalcaemia (including fatal cases); hypophosphataemia; increased risk of infection; osteonecr...

Full safety information, contraindications, and dosing available in the MedNext app.

Brand Names

Prolia(IN, PK, SA, AE, EG, ZA, NG)Xgeva(IN)
Mn

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In the MedNext App

  • Complete dosing regimens
  • Full interaction details & severity
  • AI-powered drug search
  • All 2 brand names
  • Dosing calculators
  • CME/CPD tracking
  • 40 language support
  • Offline access

Source: MedNext Audited Proprietary Dataset

Last reviewed: 2026

Medical Disclaimer: This information is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making clinical decisions. Verify all drug information with current clinical guidelines.

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